EGFLAM antibody (AA 111-210) (FITC)

Catalog No. ABIN1390730

Product Details anti-EGFLAM Antibody (FITC)

Target: EGFLAM (EGF-Like, Fibronectin Type III and Laminin G Domains (EGFLAM))

Binding Specificity: AA 111-210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGFLAM antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Pikachurin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for EGFLAM

Target: EGFLAM (EGF-Like, Fibronectin Type III and Laminin G Domains (EGFLAM))

Alternative Name: EGFLAM/Pikachurin (EGFLAM Products)

Synonyms: AGRINL antibody, AGRNL antibody, 5930412K08 antibody, AU040377 antibody, RGD1306592 antibody, EGF like, fibronectin type III and laminin G domains antibody, EGF-like, fibronectin type III and laminin G domains antibody, EGFLAM antibody, Egflam antibody

Background:

Synonyms: fibronectin type-III and laminin G-like domain-containing protein, Agrin-like protein, AGRINL, AGRNL, EGF-like, EGF-like, fibronectin type III and laminin G domains, EGF-like, fibronectin type-III and laminin G-like domain-containing protein, EGFLA_HUMAN, EGFLAM, FLJ39155, Pikachurin.

Background: EGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also promote matrix assembly and cell adhesion. Existing as five alternatively spliced isoforms, the gene encoding EGFLAM maps to human chromosome 5p13.2. Chromosome 5 makes up approximately 6 % of the human genome and contains 181 million base pairs, which encode 1,000 genes. Cockayne syndrome, Treacher Collins syndrome, acute myelogenous leukemias and myelodysplastic syndrome are associated with genes present on chromosome 5.

Pathways: Glycosaminoglycan Metabolic Process