APBA2 antibody (AA 351-450) (Biotin)

Catalog No. ABIN1392535

Product Details anti-APBA2 Antibody (Biotin)

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Binding Specificity: AA 351-450

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBA2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APBA2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for APBA2

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Alternative Name: APBA2 (APBA2 Products)

Synonyms: MGC83599 antibody, D15S1518E antibody, HsT16821 antibody, LIN-10 antibody, MGC:14091 antibody, MINT2 antibody, X11-BETA antibody, X11L antibody, X11-like antibody, XllL antibody, mXllL antibody, Mint2 antibody, amyloid beta precursor protein binding family A member 2 antibody, amyloid beta (A4) precursor protein-binding, family A, member 2 L homeolog antibody, amyloid beta (A4) precursor protein-binding, family A, member 2 antibody, APBA2 antibody, apba2.L antibody, Apba2 antibody

Background:

Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, APBA2, APBA2_HUMAN, D15S1518E, HsT16821, LIN 10, Mint 2, Mint-2, Neuron-specic X11L protein, Neuronal Munc18-1-interacting protein 2, Phosphotyrosine binding/interacting domain PTB bearing protein, X11 beta, X11l.

Background: The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer?s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the -Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).

Pathways: Synaptic Vesicle Exocytosis