COQ10B antibody (AA 38-110) (Alexa Fluor 488)

Catalog No. ABIN1392562

Product Details anti-COQ10B Antibody (Alexa Fluor 488)

Target: COQ10B (Coenzyme Q10 Homolog B (COQ10B))

Binding Specificity: AA 38-110

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ10B antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Specificity: Cross-reactivity with COQ10A (91 % homology with the immunogen sequence),

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COQ10B

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COQ10B

Target: COQ10B (Coenzyme Q10 Homolog B (COQ10B))

Alternative Name: COQ10B (COQ10B Products)

Synonyms: 1500041J02Rik antibody, 1700030I21Rik antibody, 9530077A17Rik antibody, AV002237 antibody, AW742641 antibody, RGD1359509 antibody, fc38f07 antibody, im:6912267 antibody, wu:fc38f07 antibody, zgc:112103 antibody, coenzyme Q10B antibody, COQ10B antibody, Coq10b antibody, coq10b antibody

Background:

Synonyms: Coenzyme Q10, Coenzyme Q10 B, Coenzyme Q10 homolog B, Coenzyme Q10B, CQ10B_HUMAN.

Background: COQ10B, Coenzyme Q10, is a 247 amino acid protein encoded by the human gene COQ10B. COQ10B is a mitochondrial protein that belongs to the COQ10 family. COQ10B is an essential biological cofactor which increases brain mitochondrial concentration and exerts neuroprotective effects. Plasma COQ10B levels decrease in patients with advanced chronic heart failure (CHF) while COQ10B levels in hyperthyroid patients are found among the lowest detected in human diseases. Likewise, COQ10B is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. It is believed that secretion of adrenal hormones is in some way related to COQ10B levels, both in augmented and reduced conditions. However, since thyroid hormones have an important role in modulating COQ10B levels and metabolism, when coexistent, thyroid deficiency seems to play a prevalent role in comparison with adrenal deficiency.

Gene ID: 80219

UniProt: Q9H8M1