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FIG4 antibody (AA 1-100) (Alexa Fluor 647)

FIG4 Reactivity: Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 647
Catalog No. ABIN1392762
  • Target See all FIG4 Antibodies
    FIG4 (FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (FIG4))
    Binding Specificity
    • 14
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 29
    • 16
    • 14
    • 1
    Rat
    Host
    • 43
    • 1
    Rabbit
    Clonality
    • 43
    • 1
    Polyclonal
    Conjugate
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FIG4 antibody is conjugated to Alexa Fluor 647
    Application
    • 36
    • 17
    • 12
    • 12
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Dog,Sheep,Pig,Chicken,Monkey
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FIG4
    Isotype
    IgG
    Top Product
    Discover our top product FIG4 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    FIG4 (FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (FIG4))
    Alternative Name
    FIG4/SAC3 (FIG4 Products)
    Synonyms
    A530089I17Rik antibody, AI326867 antibody, Sac3 antibody, ALS11 antibody, CMT4J antibody, KIAA0274 antibody, SAC3 antibody, YVS antibody, dJ249I4.1 antibody, Kiaa0274 antibody, RGD1311375 antibody, FIG4 phosphoinositide 5-phosphatase antibody, Fig4 antibody, FIG4 antibody
    Background

    Synonyms: 5-bisphosphate 5-phosphatase, Fig4, FIG4_HUMAN, KIAA0274, ALS11, Phosphatidylinositol 3, hSac3, Phosphatidylinositol 3,5 bisphosphate 5 phosphatase, Polyphosphoinositide phosphatase, SAC domain containing protein 3, SAC domain-containing protein 3, SAC3.

    Background: FIG4 is a 907 amino acid protein that contains one SAC domain through which it is thought to function as a phosphoinositide phosphatase that may play an important role in signal transduction and vesicle trafficking. Defects in the gene encoding FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) and amyotrophic lateral sclerosis type 11 (ALS11), both of which negatively affect the nervous system. CMT4J is a recessive demyelinating disorder of the peripheral nervous system and is characterized by reduced motor nerve conduction velocities and axonal degeneration. Unlike CMT4J, ALS11 is characterized by the degeneration of upper motor neurons in the brain and lower neurons in the spinal cord, causing paralysis and, ultimately, death.

    Pathways
    Inositol Metabolic Process
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