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PRND antibody (AA 51-120) (Alexa Fluor 350)

PRND Reactivity: Human WB, IF (p), IF (cc) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1392999
  • Target See all PRND Antibodies
    PRND (Prion Protein 2 (Dublet) (PRND))
    Binding Specificity
    • 14
    • 2
    AA 51-120
    Reactivity
    • 18
    • 4
    • 2
    Human
    Host
    • 19
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRND antibody is conjugated to Alexa Fluor 350
    Application
    • 19
    • 12
    • 12
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Doppel
    Isotype
    IgG
    Top Product
    Discover our top product PRND Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    PRND (Prion Protein 2 (Dublet) (PRND))
    Alternative Name
    Doppel/DPL (PRND Products)
    Synonyms
    PRND antibody, DOPPEL antibody, DPL antibody, PrPLP antibody, dJ1068H6.4 antibody, dpl antibody, AI450264 antibody, Dpl antibody, doppel antibody, prion like protein doppel antibody, PRND antibody, Prnd antibody
    Background

    Synonyms: DPL, Dublet, MGC41841, Prion gene complex downstream, Prion like protein doppel, Prion protein 2 dublet, Prion protein 2, Prion-like protein doppel, PRND, PRND_HUMAN, PrPLP.

    Background: Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25 % sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.

    Pathways
    Transition Metal Ion Homeostasis
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