EBF2 antibody (AA 331-400) (Alexa Fluor 350)

Catalog No. ABIN1393041

Product Details anti-EBF2 Antibody (Alexa Fluor 350)

Target: EBF2 (Early B-Cell Factor 2 (EBF2))

Binding Specificity: AA 331-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EBF2 antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EBF2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for EBF2

Target: EBF2 (Early B-Cell Factor 2 (EBF2))

Alternative Name: EBF2 (EBF2 Products)

Synonyms: EBF2 antibody, Zcoe2 antibody, D14Ggc1e antibody, EBF-2 antibody, Mmot1 antibody, O/E-3 antibody, OE-3 antibody, EBF-2-A antibody, Xcoe-2 antibody, Xcoe2 antibody, Xebf-2 antibody, Xebf-2-A antibody, Xebf2 antibody, coe2 antibody, coe2-a antibody, ebf2 antibody, oe3 antibody, COE2 antibody, early B-cell factor 2 antibody, early B cell factor 2 antibody, early B-cell factor 2 S homeolog antibody, EBF2 antibody, ebf2 antibody, Ebf2 antibody, ebf2.S antibody

Background:

Synonyms: COE 2, COE2, Collier Olf and EBF 2, Early B cell factor 2, EBF 2, FLJ11500, Metencephalon mesencephalnon olfactory transcription factor 1, O/E 3, O/E3, OE 3, OE3, OLF 1/EBF like 3, Transcription factor COE2, COE2_HUMAN.

Background: Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member.

Gene ID: 64641

UniProt: Q9HAK2