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NUMBL antibody (AA 75-120) (Alexa Fluor 488)

NUMBL Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN1394416
  • Target See all NUMBL Antibodies
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Binding Specificity
    • 14
    • 9
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    AA 75-120
    Reactivity
    • 46
    • 9
    • 9
    • 1
    Human
    Host
    • 44
    • 1
    • 1
    Rabbit
    Clonality
    • 45
    • 1
    Polyclonal
    Conjugate
    • 12
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NUMBL antibody is conjugated to Alexa Fluor 488
    Application
    • 31
    • 22
    • 16
    • 12
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NUMBL
    Isotype
    IgG
    Top Product
    Discover our top product NUMBL Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Alternative Name
    NUMBL (NUMBL Products)
    Synonyms
    nbl antibody, numb antibody, cag3a antibody, ctg3a antibody, numbr antibody, numb-r antibody, tnrc23 antibody, numblike antibody, CAG3A antibody, CTG3a antibody, NBL antibody, NUMB-R antibody, NUMBLIKE antibody, NUMBR antibody, TNRC23 antibody, NUMB like, endocytic adaptor protein antibody, numb homolog-like L homeolog antibody, NUMB-like, endocytic adaptor protein antibody, numb-like antibody, NUMBL antibody, numbl.L antibody, Numbl antibody
    Background

    Synonyms: CAG 3A, CAG3A, CTG 3a, CTG3a, NBL, NUMB Drosophilia Homolog Like, Numb homolog Drosophila like, Numb homolog like, Numb like protein, NUMB R, Numb-like protein, Numb-R, Numb-related protein, NUMBL, NUMBL_HUMAN, NUMBR, TNRC 23, TNRC23.

    Background: In Drosophila, neuronal cell fate decisions are directed by NUMB, a signaling adapter protein with two protein-protein interaction domains, namely a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.

    Pathways
    Cell-Cell Junction Organization
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