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FBXW8 antibody (F-Box and WD Repeat Domain Containing 8) AA 181-280 (FITC) Primary Antibody

FBXW8 Reactivity: Rat IF (cc), IF (p) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1398842
$476.30
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target See all FBXW8 Antibodies
    FBXW8
    Binding Specificity
    • 14
    • 8
    • 8
    • 7
    • 7
    • 3
    • 1
    • 1
    • 1
    AA 181-280
    Reactivity
    • 22
    • 15
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Rat
    Host
    • 35
    • 1
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXW8 antibody is conjugated to FITC
    Application
    • 25
    • 17
    • 14
    • 14
    • 12
    • 12
    • 5
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBXW8/FBXO29
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    FBXW8
    Alternative Name
    FBXW8 (FBXW8 Products)
    Synonyms
    FBW6, FBW8, FBX29, FBXO29, FBXW6, 4930438M06Rik, Fbx29, F-box and WD repeat domain containing 8, ring finger protein, transmembrane 2, F-box and WD-40 domain protein 8, FBXW8, Fbxw8, RNFT2
    Background

    FBXO29, also designated F-box/WD repeat-containing protein 8 (FBXW8), is a 598 amino acid protein that contains one 40 amino acid F-box region, making it a member of the F-box family. FBXO29 also contains five WD repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and -catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO29 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation. FBXO29 exists as two isoforms as a result of alternative splicing events.

    Subcellular location: Cytoplasm

    Synonyms: F box/WD repeat containing protein 8; F box and WD40 domain containing protein 8; F-box only protein 29; F box only protein 29; FBW6; FBW8; FBX29; FBXO29; FBXW6; FBXW8_HUMAN.

    Gene ID
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