APLP2 antibody (Amyloid beta (A4) Precursor-Like Protein 2) AA 501-600 (Alexa Fluor 350)

Catalog No. ABIN1399227

Product Details anti-APLP2 Antibody

Target: APLP2

Binding Specificity: AA 501-600

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP2 antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APLP2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for APLP2

Target: APLP2

Alternative Name: APLP2 (APLP2 Products)

Synonyms: HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14, APLP-2, APPH, APPL2, CDEBP, AI790698, Apph, WALPLP2, aplp2 B, APLP2, si:dkey-11k4.3, aplp2 A, MGC86389, suppression of tumorigenicity 14, amyloid beta precursor like protein 2, amyloid beta (A4) precursor-like protein 2, amyloid beta (A4) precursor-like protein 2 S homeolog, amyloid beta (A4) precursor-like protein 2 L homeolog, ST14, APLP2, Aplp2, aplp2.S, aplp2, aplp2.L

Background:

APLP2 is a human sperm membrane protein which contains a segment with high homology to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer disease patients. The human amyloid precursor-like protein APLP2 is a highly conserved homolog of a sequence-specific DNA-binding mouse protein with an important function in the cell cycle. The gene which encodes APLP2 maps to human chromosome 11q24.May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.

Subcellular location: Nucleus, Cell membrane

Synonyms: amyloid beta A4 precursor like protein 2, Amyloid like protein 2, amyloid precursor protein homolog HSD2, Amyloid protein homolog, Amyloid-like protein 2, APLP-2, Aplp2, APLP2_HUMAN, APPH, APPL2, CDEBP, CDEI box binding protein, CDEI box-binding protein.

Gene ID:

Pathways: EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Feeding Behaviour