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FBXO25 antibody (Alexa Fluor 555)

FBXO25 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal Alexa Fluor 555
Catalog No. ABIN1399349
  • Target See all FBXO25 Antibodies
    FBXO25 (F-Box Protein 25 (FBXO25))
    Reactivity
    • 27
    • 18
    • 16
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 28
    • 2
    Rabbit
    Clonality
    • 28
    • 2
    Polyclonal
    Conjugate
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXO25 antibody is conjugated to Alexa Fluor 555
    Application
    • 25
    • 11
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Pig,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBXO25
    Isotype
    IgG
    Top Product
    Discover our top product FBXO25 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    FBXO25 (F-Box Protein 25 (FBXO25))
    Alternative Name
    FBXO25 (FBXO25 Products)
    Synonyms
    FBXO25 antibody, fbxo32 antibody, MGC108443 antibody, DKFZp469H2437 antibody, zgc:100907 antibody, FBX25 antibody, 9130015I06Rik antibody, AI649137 antibody, Fbx25 antibody, F-box protein 25 antibody, F-box protein 25 L homeolog antibody, FBXO25 antibody, fbxo25 antibody, fbxo25.L antibody, Fbxo25 antibody
    Background

    Synonyms: F box only protein 25, F box protein 25, F box protein Fbx25, F-box only protein 25, FBX25, MGC20256, MGC51975, OTTHUMP00000115399,

    Background: FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing.FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation.

    Gene ID
    26260
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