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MLLT11 antibody (AA 41-90) (Alexa Fluor 647)

MLLT11 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 647
Catalog No. ABIN1399740
  • Target See all MLLT11 Antibodies
    MLLT11 (Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog), Translocated To, 11 (MLLT11))
    Binding Specificity
    • 14
    • 6
    • 1
    • 1
    • 1
    AA 41-90
    Reactivity
    • 23
    • 3
    • 2
    Human
    Host
    • 22
    • 2
    Rabbit
    Clonality
    • 22
    • 2
    Polyclonal
    Conjugate
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLLT11 antibody is conjugated to Alexa Fluor 647
    Application
    • 12
    • 12
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MLLT11
    Isotype
    IgG
    Top Product
    Discover our top product MLLT11 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MLLT11 (Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog), Translocated To, 11 (MLLT11))
    Alternative Name
    MLLT11 (MLLT11 Products)
    Synonyms
    AF1Q antibody, RP11-316M1.10 antibody, AI839562 antibody, Af1q antibody, Zfp692 antibody, RGD1305525 antibody, fc23g02 antibody, si:ch211-210h11.4 antibody, wu:fc23g02 antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 antibody, MLLT11, transcription factor 7 cofactor antibody, MLLT11 antibody, Mllt11 antibody, mllt11 antibody
    Background

    Synonyms: AF1Q, ALL1 fused gene from chromosome 1q, MLLT 11, MLLT-11, Myeloid/lymphoid or mixed lineage leukemia trithorax homolog, Drosophila translocated to 11, Protein AF1q, RP11 316M1.10.

    Background: The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10 % of patients with acute lymphoblastic leukemia (ALL) and 5 % of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. MLLT11, also known as mixed-lineage leukemia translocated to 11 or AF1q, is a 90 amino acid MLL fusion partner. Based on the expression patterns of MLLT11, it is thought that MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML). Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Finally, MLLT11 has been shown to be differentially expressed in highly metastatic cells, in comparison with non-metastatic parent cells. Such findings suggest a role of MLLT11 in tumorigenesis.

    Gene ID
    10962
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