MEPE antibody (AA 201-300) (Alexa Fluor 647)

Catalog No. ABIN1400190

Product Details anti-MEPE Antibody (Alexa Fluor 647)

Target: MEPE (Matrix Extracellular phosphoglycoprotein (MEPE))

Binding Specificity: AA 201-300

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEPE antibody is conjugated to Alexa Fluor 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MEPE

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MEPE

Target: MEPE (Matrix Extracellular phosphoglycoprotein (MEPE))

Alternative Name: MEPE (MEPE Products)

Synonyms: OF45 antibody, OC-116 antibody, Of45 antibody, matrix extracellular phosphoglycoprotein antibody, matrix extracellular phosphoglycoprotein with ASARM motif (bone) antibody, MEPE antibody, Mepe antibody, LOC789774 antibody

Background:

Synonyms: Matrix extracellular phosphoglycoprotein, MEPE, MEPE_HUMAN, OF45, Osteoblast/osteocyte factor 45.

Background: MEPE is a 525 amino acid extracellular matrix protein. Expressed in osteocytes and brain, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment. MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, including OPN (osteopontin) and DSP (dentin sialophosphoprotein). Via its ability to control bone mineralization, MEPE is associated with various developmental events such as skeletogenesis, bone regeneration and odontogenesis. MEPE is secreted in hypophosphatemic osteomalacia tumors, suggesting a possible role in the pathophysiology of bone-related cancers.

Gene ID: 56955