Cystatin D (CST5) antibody (Alexa Fluor 350)

Details for Product No. ABIN1401507, Supplier: Log in to see
Antigen
  • DD72
  • Cystatin-5
  • Cst10
  • cystatin D
  • cystatin 10 (chondrocytes)
  • CST5
  • Cst10
  • Cst5
Reactivity
Human
40
4
Host
Rabbit
22
18
2
1
Clonality
Polyclonal
Conjugate
Alexa Fluor 350
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
24
12
4
4
4
2
1
1
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human Cystatin D
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Cystatin D (CST5 Antibody Abstract)
Background

The cystatin superfamily is a well-established family of cysteine protease inhibitors. Cystatins A and B (type 1) are mainly intracellular, cystatins C, D, E/M, F, G, S, SN and SA cystatins are extracellular (type 2), and the kininogens are type 3 cystatins which are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes. Cystatin SA, cystatin S and cystatin SN are found primarily in saliva. Cystatin S and SN can also be expressed in tears, urine and seminal fluid. Cystatin C is a related protein which is expressed in brain, thymus, ovary, epididymis and vas deferens. Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins. The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors and the response to systemic inflammation. High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) have varied roles, though they both inhibit the thrombin- and plasmin-induced aggregation of thrombocytes.

Synonyms: CST 5, CST5, Cystatin 5, Cystatin5, Cystatin-5, CystatinD, Cystatin D, Cysteine proteinase inhibitor, MGC71922, CYTD_HUMAN.

Gene ID 1473
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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