RPE65 antibody (Alexa Fluor 350)

Catalog No. ABIN1403487

Product Details anti-RPE65 Antibody (Alexa Fluor 350)

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPE65 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RPE65

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RPE65

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Alternative Name: RPE65 (RPE65 Products)

Synonyms: LCA2 antibody, RP20 antibody, mRPE65 antibody, rd12 antibody, sRPE65 antibody, 65kDa antibody, A930029L06Rik antibody, Mord1 antibody, DRPE65 antibody, RPE65 antibody, anon-WO0148162.1 antibody, anon-WO0148163.1 antibody, beta-diox antibody, DmelCG9347 antibody, CG9347 antibody, MGC52887 antibody, MGC154296 antibody, MGC85437 antibody, rpe65 antibody, RPE56c antibody, si:ch211-198n5.12 antibody, 13cIMH antibody, RPE56b antibody, rpepb antibody, si:ch211-198n5.5 antibody, wu:fc74c09 antibody, zgc:110538 antibody, RPE56a antibody, rpepa antibody, zgc:73213 antibody, RPE65, retinoid isomerohydrolase antibody, retinal pigment epithelium 65 antibody, neither inactivation nor afterpotential B antibody, retinal pigment epithelium-specific protein 65kDa S homeolog antibody, retinal pigment epithelium-specific protein 65kDa L homeolog antibody, RPE65 homolog antibody, retinal pigment epithelium-specific protein 65kDa antibody, retinal pigment epithelium-specific protein 65c antibody, retinal pigment epithelium-specific protein 65b antibody, retinal pigment epithelium-specific protein 65a antibody, RPE65 antibody, Rpe65 antibody, ninaB antibody, rpe65.S antibody, rpe65.L antibody, rpe65 antibody, rpe65c antibody, rpe65b antibody, rpe65a antibody

Background:

Synonyms: All-trans-retinyl-palmitate hydrolase, LCA 2, LCA2, Leber congenital amaurosis, mRPE 65, mRPE65, p63, rd 12, rd12, Retinal pigment epithelium specic 61 kDa protein, Retinal pigment epithelium specic 65 kDa protein, Retinal pigment epithelium specic protein, Retinal pigment epithelium specic protein 65 kDa, Retinal pigment epithelium-specic 65 kDa protein, Retinitis pigmentosa 20, Retinoid isomerohydrolase, RP 20, RP20, RPE 65, RPE65, RPE65_HUMAN, sRPE 65, sRPE65.

Background: The retinal pigment epithelium (RPE) is a monolayer simple epithelium in proximity to the outer surface of the retinal photoreceptor cells. Retinal pigment epithelium-specific protein (RPE65) is a 65 kDa protein belonging to the _-carotene dioxygenase family. This protein is important in 11-cis retinal production as well as in visual pigment regeneration. RPE65 is attached to the membrane by a lipid anchor when palmitoylated (membrane form) and soluble when unpalmitoylated. The soluble form of the protein binds vitamin A. Defects in RPE65 causes autosomal dominant retinitis pigmentosa and/or Leber congenital amaurosis type 2.