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SORCS1 antibody (AA 561-660) (HRP)

SORCS1 Reactivity: Human ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal HRP
Catalog No. ABIN1408526
  • Target See all SORCS1 Antibodies
    SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))
    Binding Specificity
    • 14
    • 10
    • 7
    • 5
    • 4
    AA 561-660
    Reactivity
    • 35
    • 2
    Human
    Host
    • 35
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SORCS1 antibody is conjugated to HRP
    Application
    • 17
    • 17
    • 13
    • 13
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SORCS1
    Isotype
    IgG
    Top Product
    Discover our top product SORCS1 Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))
    Alternative Name
    SORCS1 (SORCS1 Products)
    Synonyms
    hSorCS antibody, Sorcs antibody, mSorCS antibody, sortilin related VPS10 domain containing receptor 1 antibody, sortilin-related VPS10 domain containing receptor 1 antibody, SORCS1 antibody, Sorcs1 antibody
    Background

    Synonyms: SorCS 1, SORCS, SORCS-1, SORCS receptor 1, Sortilin related VPS10 domain containing receptor 1, VPS10 domain containing receptor SorCS1, VPS10 domain receptor protein SORCS 1, VPS10 domain receptor protein SORCS, VPS10 domain receptor protein SORCS1, VPS10 domain receptor SorCS, FLJ41758, FLJ43475, FLJ44957, hSorCS, OTTHUMP00000058855, SORC1_HUMAN.

    Background: There are three sorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, the homologous SorCS1 and SorCS2 genes and the SorCS3 gene are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS1 is a type 1 receptor containing a VPS10P domain and a leucine-rich domain. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic tails and differential expression in tissues. Human SorCS1 is detected in fetal and infant brain and in fetal retina. Alternative splicing of murine SorCS1 also results in four isoforms. Murine isoform 1 is highly expressed in brain and at lower levels in heart, liver and kidney. It is detected in newborn mouse brain and in adult olfactory bulb and cerebral cortex. Murine isoform 2 is highly expressed in liver and at lower levels in heart, brain, kidney and testis.

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