NOMO1 antibody (AA 701-800) (HRP)

Catalog No. ABIN1410098

Product Details anti-NOMO1 Antibody (HRP)

Target: NOMO1 (NODAL Modulator 1 (NOMO1))

Binding Specificity: AA 701-800

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOMO1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOMO1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NOMO1

Target: NOMO1 (NODAL Modulator 1 (NOMO1))

Alternative Name: NOMO1 (NOMO1 Products)

Synonyms: Nomo antibody, PM5 antibody, D7Ertd156e antibody, pM5 antibody, RGD1305240 antibody, NOMO2 antibody, DKFZP459L1733 antibody, Nomo1 antibody, NODAL modulator 1 antibody, nodal modulator 1 antibody, NOMO1 antibody, Nomo1 antibody, LOC515570 antibody, LOC714226 antibody, LOC100025365 antibody, LOC100174326 antibody, LOC100408200 antibody, LOC100464689 antibody, LOC100544619 antibody, LOC100626015 antibody, LOC454345 antibody, LOC489992 antibody, LOC100713781 antibody

Background:

Synonyms: Nodal modulator 1, NOMO 1, Nomo, NOMO1, NOMO1_HUMAN, PM5, pM5 protein, pM5 protein telomeric copy, NOMO1_HUMAN.

Background: Three highly similar proteins termed NOMO1, NOMO2 and NOMO3, are encoded by a gene mapping to a region of duplication on the p arm of human chromosome 16. All three NOMO proteins share similar functions and have been difficult to characterize individually. NOMO1 (Nodal modulator 1), also known as PM5, is a 1,222 amino acid highly conserved single-pass type I membrane protein expressed in colon tumor tissue and normal colonic mucosa. NOMO proteins are novel antagonists of Nodal signaling which interact with Nicalin to form a Nicalin-NOMO complex, and are rapidly degraded or stabilized by Nicalin. NOMO proteins were once considered candidates for the development of pseudoxanthoma elasticum (PXE), a heritable disorder of connective tissue, as the NOMO genes are located in close proximity to the gene responsible for PXE development (MRP6).