AFF2 antibody (AA 1-80) (Cy7)

Catalog No. ABIN1410732

Product Details anti-AFF2 Antibody (Cy7)

Target: AFF2 (AF4/FMR2 Family, Member 2 (AFF2))

Binding Specificity: AA 1-80

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFF2 antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AFF2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AFF2

Target: AFF2 (AF4/FMR2 Family, Member 2 (AFF2))

Alternative Name: FMR2/AFF2 (AFF2 Products)

Synonyms: FMR2 antibody, FMR2P antibody, FRAXE antibody, MRX2 antibody, OX19 antibody, Fmr2 antibody, Ox19 antibody, Oxh antibody, AF4/FMR2 family member 2 antibody, AF4/FMR2 family, member 2 antibody, AFF2 antibody, Aff2 antibody

Background:

Synonyms: AF4/FMR2 family member 2, AF4/FMR2 family, member 2, AFF2, AFF2_HUMAN, FMR2, FMR2P, Fragile X E mental retardation syndrome protein, fragile X mental retardation 2, Fragile X mental retardation 2 protein, fragile X mental retardation gene associated with FRAXE, FRAXE, mild or borderline mental retardation, MRX2, OX19, Protein FMR-2, Protein Ox19.

Background: FMR2 is a 1311 amino acid nuclear protein belonging to the AF4 family. Expressed in the brain, placenta and lung, FMR2 exists as two isoforms produced by alternative splicing. Defects in the gene that encodes FMR2 have been found to be a cause of FRAXE, an X-linked form of mental retardation. Individuals expressing the FRAXE site also have more than two-hundred copies of a GCC repeat adjacent to CpG island, compared to six to thirty-five copies of the GCC repeat in a normal individual. It is believed that loss of FMR2 expression causes this GCC expansion of the FRAXE site.