POP1 antibody (HRP)

Catalog No. ABIN1418752

Product Details anti-POP1 Antibody (HRP)

Target: POP1 (Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POP1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ASC2/POP1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for POP1

Target: POP1 (Processing of Precursor 1, Ribonuclease P/MRP Subunit (S. Cerevisiae) (POP1))

Alternative Name: POP1 (POP1 Products)

Synonyms: 4932434G09Rik antibody, POP1 homolog, ribonuclease P/MRP subunit antibody, processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) antibody, POP1 antibody, Pop1 antibody

Background:

Synonyms: PAAD domain only protein, POP1, PYDC1, Pyrin domain containing 1, Pyrin only protein 1, PYDC1_HUMAN.

Background: The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel -helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-B and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes.

Gene ID: 10940