COPS2 antibody (PE-Cy5.5)

Catalog No. ABIN1434560

The Rabbit Polyclonal anti-COPS2 antibody has been validated for WB. It is suitable to detect COPS2 in samples from Human, Mouse, Rat, Cow, Dog and Pig.

Quick Overview for COPS2 antibody (PE-Cy5.5) (ABIN1434560)

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS2 antibody is conjugated to PE-Cy5.5

Application: Western Blotting (WB)

Product Details anti-COPS2 Antibody (PE-Cy5.5)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPS2/TRIP15

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COPS2

Target: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Alternative Name: COPS2

Background:

Synonyms: ALIEN, Alien homolog, COP 9, COP9, COP9 constitutive photomorphogenic homolog subunit 2, COP9 signalosome complex subunit 2, COPS 2, Cops2, CSN2, CSN2_HUMAN, JAB1 containing signalosome subunit 2, JAB1-containing signalosome subunit 2, SGN 2, SGN2, Signalosome subunit 2, Thyroid Hormone Receptor Interactor15, Thyroid Hormone Receptor Interactor 15, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP 15, TRIP-15.

Background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Molecular Weight: 51kDa

Gene ID: 1447

Pathways: Cell Division Cycle