GCLM antibody (N-Term)

Catalog No. ABIN1449395

Product Details anti-GCLM Antibody

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Binding Specificity: AA 1-274, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GCLM antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human GCLM (1-274aa) purified from E. coli

Clone: AT2D12

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate -Buffered Saline ( pH 7.4) with 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GCLM

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Alternative Name: GCLM / GLCLR (GCLM Products)

Synonyms: Glclr antibody, GLCLR antibody, id:ibd3182 antibody, wu:fi24c07 antibody, zgc:55903 antibody, AI649393 antibody, Gcmc antibody, glutamate-cysteine ligase regulatory subunit antibody, glutamate cysteine ligase, modifier subunit antibody, glutamate-cysteine ligase modifier subunit antibody, glutamate-cysteine ligase, modifier subunit antibody, glutamate-cysteine ligase, modifier subunit L homeolog antibody, PTRG_09814 antibody, Gclm antibody, GCLM antibody, gclm antibody, gclm.L antibody

Background: GCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer.Synonyms: GCS light chain, Gamma-ECS regulatory subunit, Gamma-glutamylcysteine synthetase regulatory subunit, Glutamate-cysteine ligase modifier subunit, Glutamate-cysteine ligase regulatory subunit

Gene ID: 2730

NCBI Accession: NP_002052

UniProt: P48507