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ATG4A antibody (C-Term)

ATG4A Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1449633
  • Target See all ATG4A Antibodies
    ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))
    Binding Specificity
    • 15
    • 11
    • 11
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 369-398, C-Term
    Reactivity
    • 68
    • 28
    • 22
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 61
    • 4
    • 2
    • 1
    Rabbit
    Clonality
    • 64
    • 4
    Polyclonal
    Conjugate
    • 30
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATG4A antibody is un-conjugated
    Application
    • 45
    • 27
    • 25
    • 20
    • 14
    • 13
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Purification
    Saturated Ammonium Sulfate precipitation followed by dialysis against PBS
    Immunogen
    KLH conjugated synthetic peptide between 369~398 amino acids from the C-term of Human APG4A
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ATG4A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))
    Alternative Name
    Autophagin-2 (ATG4A Products)
    Synonyms
    apg4a antibody, autl2 antibody, F6E13.27 antibody, APG4A antibody, zgc:111958 antibody, Aut2a antibody, AUTL2 antibody, AI627006 antibody, AV169859 antibody, Apg4a antibody, Atg4al antibody, Autl2 antibody, Atg4a antibody, autophagy related 4A cysteine peptidase L homeolog antibody, autophagy related 4A cysteine peptidase antibody, Peptidase family C54 protein antibody, ATG4 autophagy related 4 homolog A (S. cerevisiae) antibody, autophagy related 4A, cysteine peptidase antibody, atg4a.L antibody, ATG4A antibody, AT2G44140 antibody, atg4a antibody, Atg4a antibody
    Background
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.Synonyms: APG4A, ATG4A, AUT-like 2 cysteine endopeptidase, AUTL2, Autophagy-related cysteine endopeptidase 2, Autophagy-related protein 4 homolog A, Cysteine protease ATG4A
    Molecular Weight
    45378 Da
    Gene ID
    115201
    NCBI Accession
    NP_443168
    Pathways
    Autophagy
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