TCIRG1 antibody (N-Term)

Catalog No. ABIN1450004

The Rabbit Polyclonal anti-TCIRG1 antibody has been validated for WB and EIA. It is suitable to detect TCIRG1 in samples from Human, Mouse and Rat.

Quick Overview for TCIRG1 antibody (N-Term) (ABIN1450004)

Target: TCIRG1 (T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCIRG1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-TCIRG1 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: A 19 amino acid synthetic peptide near the amino terminus of Human TCIRG1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for TCIRG1

Target: TCIRG1 (T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1))

Alternative Name: TCIRG1 / ATP6N1C

Background: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.Synonyms: ATP6V0A3, Osteoclastic proton pump 116 kDa subunit, T-cell immune regulator 1, T-cell immune response cDNA7 protein, V-ATPase 116 kDa isoform a3, V-type proton ATPase 116 kDa subunit a isoform 3, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3

Molecular Weight: 91 kDa

Gene ID: 10312

NCBI Accession: NP_006010

Pathways: Transition Metal Ion Homeostasis, Proton Transport