PRICKLE1 antibody (C-Term)

Catalog No. ABIN1450074

Product Details anti-PRICKLE1 Antibody

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRICKLE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRICKLE1

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Alternative Name: PRICKLE1 (PRICKLE1 Products)

Synonyms: EPM1B antibody, RILP antibody, Rilp antibody, 1110058P22Rik antibody, AW215793 antibody, Prickle antibody, mpk1 antibody, XPk antibody, pk-B antibody, prickle antibody, prickle-B antibody, Prickle-b antibody, prickle planar cell polarity protein 1 antibody, prickle planar cell polarity protein 1 L homeolog antibody, prickle planar cell polarity protein 1 S homeolog antibody, PRICKLE1 antibody, Prickle1 antibody, prickle1.L antibody, prickle1.S antibody

Background: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.Synonyms: PRICKLE-1, Prickle-like protein 1, REST/NRSF-interacting LIM domain protein 1, RILP

Gene ID: 144165

NCBI Accession: NP_694571

Pathways: WNT Signaling, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development, Protein targeting to Nucleus