PRICKLE2 antibody (Middle Region)

Catalog No. ABIN1450075

Product Details anti-PRICKLE2 Antibody

Target: PRICKLE2 (Prickle Homolog 2 (PRICKLE2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRICKLE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the center of human PRICKLE2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PRICKLE2

Target: PRICKLE2 (Prickle Homolog 2 (PRICKLE2))

Alternative Name: PRICKLE2 (PRICKLE2 Products)

Synonyms: EPM5 antibody, 6230400G14Rik antibody, 6720451F06Rik antibody, mpk2 antibody, cb886 antibody, im:7138215 antibody, pk2 antibody, prickle planar cell polarity protein 2 antibody, prickle homolog 2b antibody, PRICKLE2 antibody, Prickle2 antibody, prickle2b antibody

Background: PRICKLE2, also known as Pk2 or EPM5, is a member of a highly conserved protein family that function in the noncanonical WNT signaling pathway which regulates intracellular calcium release and planar cell polarity. Both PRICKLE2 and the related protein PRICKLE1 are expressed in postmitotic neurons and promote neurite outgrowth, and both proteins promote neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. PRICKLE2 localizes to the postsynaptic density and interacts with PSD-95 and NMDA receptors. Defects in the gene encoding PRICKLE2 are associated with autosomal recessive progressive myoclonic epilepsy.Synonyms: PRICKLE-2, Prickle-like protein 2

Gene ID: 166336

NCBI Accession: NP_942559