TACI antibody (PE)

Catalog No. ABIN1504150

Product Details anti-TACI Antibody (PE)

Target: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TACI antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: This antibody reacts with CD267 antigen. Clone 11H3 has an agonistic activity and it doesn't block binding of BAFF to TACI.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Clone: 11H3

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 50 tests in 1 mLvolume of PBS containing 1 % BSA and 0.09 % NaN3

Target Details for TACI

Target: TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))

Alternative Name: CD267 / TACI (TNFRSF13B Products)

Synonyms: CD267 antibody, CVID antibody, CVID2 antibody, RYZN antibody, TACI antibody, TNFRSF14B antibody, TNFRSF13B antibody, 1200009E08Rik antibody, Taci antibody, TNF receptor superfamily member 13B antibody, tumor necrosis factor receptor superfamily, member 13b antibody, TNFRSF13B antibody, Tnfrsf13b antibody

Background: CD267, also known as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) or TNFRSF13B, is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF/CD257) and as a proliferation-inducing ligand (APRIL/CD256). BAFF and APRIL bind both TACI and BCMA (B cell maturation Ag/CD269), with BAFF additionally and exclusivel y binding the BAFF receptor (BAFF-R/CD268) while APRIL can also bind to heparin sulfate proteoglycan s (HSPG). TACI is expressed on B cells and activated T cells. BC MA is exclusively expressed on B cells, whereas BAFF-R is expressed mainly on B cells but also on T cells. It is reported that mutations of CD267/TACI are showed in patients with IgA deficiency and common variable immunodeficiency (CVID). Sakurai et al ., reported that TACI positively regulated APRIL-induced IgA production in collaboration with HSPG and TACI negatively regulated BAFF-induced B-cell proliferation and production of IgA and IgG.Synonyms: TNFRSF13B, Transmembrane activator and CAML interactor, Tumor necrosis factor receptor superfamily member 13B

Gene ID: 23495