PTPN22 antibody (AA 1-90)

Catalog No. ABIN1513449

Product Details anti-PTPN22 Antibody

Target: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Binding Specificity: AA 1-90

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN22 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PTPN22 (NP_036543.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PTPN22

Target: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Alternative Name: PTPN22 (PTPN22 Products)

Synonyms: 70zpep antibody, PEP antibody, Ptpn8 antibody, LYP antibody, LYP1 antibody, LYP2 antibody, PTPN8 antibody, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antibody, protein tyrosine phosphatase, non-receptor type 22 antibody, Ptpn22 antibody, PTPN22 antibody

Background: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.,PTPN22,LYP,LYP1,LYP2,PEP,PTPN22.5,PTPN22.6,PTPN8,Signal Transduction,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,PTPN22

Molecular Weight: 20 kDa/75 kDa/78 kDa/85 kDa/88 kDa/91 kDa

Gene ID: 26191

UniProt: Q9Y2R2