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SPAM1 antibody (AA 100-300)

SPAM1 Reactivity: Human WB, IF, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1513554
  • Target See all SPAM1 Antibodies
    SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 100-300
    Reactivity
    • 19
    • 3
    • 3
    Human
    Host
    • 18
    • 1
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPAM1 antibody is un-conjugated
    Application
    • 8
    • 7
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Sequence
    PYIDSITGVT VNGGIPQKIS LQDHLDKAKK DITFYMPVDN LGMAVIDWEE WRPTWARNWK PKDVYKNRSI ELVQQQNVQL SLTEATEKAK QEFEKAGKDF LVETIKLGKL LRPNHLWGYY LFPDCYNHHY KKPGYNGSCF NVEIKRNDDL SWLWNESTAL YPSIYLNTQQ SPVAATLYVR NRVREAIRVS KIPDAKSPLP V
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human SPAM1 (NP_003108.2).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
    Alternative Name
    SPAM1 (SPAM1 Products)
    Synonyms
    AV039194 antibody, Ph-20 antibody, PH-20 antibody, PH20 antibody, HYA1 antibody, HYAL1 antibody, HYAL3 antibody, HYAL5 antibody, SPAG15 antibody, Spam antibody, XEH1 antibody, spam1 antibody, im:6902904 antibody, zgc:158668 antibody, sperm adhesion molecule 1 antibody, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog antibody, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antibody, Spam1 antibody, SPAM1 antibody, spam1.L antibody, spam1 antibody
    Background
    Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.,SPAM1,HEL-S-96n,HYA1,HYAL1,HYAL3,HYAL5,PH-20,PH20,SPAG15,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,SPAM1
    Molecular Weight
    57 kDa/58 kDa
    Gene ID
    6677
    UniProt
    P38567
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