NR4A2 antibody (AA 310-360)

Catalog No. ABIN1574115

Product Details anti-NR4A2 Antibody

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Binding Specificity: AA 310-360

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR4A2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Nurr1 Antibody, pAb, Rabbit detects human Nurr1 protein. Predicted to react with rat and mouse Nurr1 protein according to sequence homology.

Cross-Reactivity (Details): Nurr1 Antibody, pAb, Rabbit detects human Nurr1 protein. Predicted to react with rat and mouse Nurr1 protein according to sequence homology.

Purification: Immunoaffinity chromatography

Immunogen: KLH-coupled synthetic peptide within AA 310~360 of human Nurr1 protein

Isotype: IgG2b

Application Details

Application Notes: Working concentrations for specific applications should be determined by the investigator. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Western blot: 1-2 µg/mL Other Applications: user-optimized

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C/-20 °C

Storage Comment: The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.

Target Details for NR4A2

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Alternative Name: Nurr1 (NR4A2 Products)

Synonyms: nr41/42/43 antibody, Nr4a2 antibody, nurr1 antibody, not antibody, rnr1 antibody, hzf-3 antibody, tinur antibody, NGFI-B antibody, HZF-3 antibody, NOT antibody, NURR1 antibody, RNR1 antibody, TINUR antibody, Nurr1 antibody, RNR-1 antibody, TINOR antibody, ngf1b antibody, nr4a2 antibody, zgc:92696 antibody, nuclear receptor subfamily 4 group A member 2 antibody, nuclear receptor antibody, nuclear receptor subfamily 4, group A, member 2 antibody, nuclear receptor subfamily 4, group A, member 2b antibody, NR4A2 antibody, nr41/42/43 antibody, nr4a2 antibody, Nr4a2 antibody, nr4a2b antibody

Background: Nurr1 is a transcription factor and belongs to the Nur77 family of orphan receptors. This family of transcription factors plays key roles in the development and the effector functions of T lymphocytes. Nurr1 promote signaling via its heterodimerization partner, the retinoid X receptor (RXR). Nurr1 protein is expressed in the embryonic ventral midbrain and it is critical for the development of dopamine neurons. In addition, Nurr1 has been implicated in the maintenance of adult dopaminergic neurons. Nurr1 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 310~360 of human Nurr1 protein (Swiss Prot: P43354).

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway