TYK2 antibody (N-Term)

Catalog No. ABIN1077422

Product Details anti-TYK2 Antibody

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least three isoforms of TYK2 are known to exist, this antibody only detects the two longest isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2.

Isotype: IgG

Application Details

Application Notes: TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 μg/mL.

Comment:

(NT) Tyrosine kinase 2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: TYK2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: TYK2 (TYK2 Products)

Synonyms: JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody

Background: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Synonyms: Tyrosine kinase 2, non-receptor tyrosine kinase 2

Molecular Weight: 131 kDa (calculated)

Gene ID: 7297

NCBI Accession: NP_003322

Pathways: JAK-STAT Signaling, Hepatitis C