FAM193B antibody (N-Term)

Catalog No. ABIN1587943

Product Details anti-FAM193B Antibody

Target: FAM193B (Family with Sequence Similarity 193, Member B (FAM193B))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM193B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Specificity: At least two isoforms of FAM193B are known to exist, this antibody will detect both isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: FAM193B antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FAM193B.

Isotype: IgG

Application Details

Application Notes: FAM193B antibody can be used for detection of FAM193B by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Comment:

(NT) Family with sequence similarity 193 member B

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: FAM193B antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for FAM193B

Target: FAM193B (Family with Sequence Similarity 193, Member B (FAM193B))

Alternative Name: FAM193B (FAM193B Products)

Background: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.

Molecular Weight: 99 kDa

Gene ID: 54540

UniProt: Q96PV7