CD247 antibody

Catalog No. ABIN161386

Product Details anti-CD247 Antibody

Target: CD247 (CD247 Molecule (CD247))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This CD247 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Specificity: Mouse CD3z (zeta chain) also known as CD247

Purification: Purified

Immunogen: KLH conjugated mouse zeta-chain (CD3) sequence 151-164 . Donor: Armenian hamster

Clone: H146-968

Isotype: IgG

Application Details

Application Notes: This clone (H146-968) has been reported to work in flow cytometry (in permeabilized cells), Western Blotting and ELISA.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/ml

Storage: 4 °C

Target Details for CD247

Target: CD247 (CD247 Molecule (CD247))

Alternative Name: CD3z (CD247 Products)

Synonyms: CD3-ZETA antibody, CD3H antibody, CD3Q antibody, CD3Z antibody, T3Z antibody, TCRZ antibody, 4930549J05Rik antibody, A430104F18Rik antibody, AW552088 antibody, Cd3 antibody, Cd3-eta antibody, Cd3-zeta antibody, Cd3h antibody, Cd3z antibody, Cd3zeta antibody, T3z antibody, Tcrk antibody, Tcrz antibody, LOC100136514 antibody, LOC100136549 antibody, LOC100305023 antibody, CD247 antibody, TCRzeta antibody, CD247 molecule antibody, CD247 antigen antibody, CD3zeta-2 antibody, CD3zeta-1 antibody, Cd247 molecule antibody, CD247 antibody, Cd247 antibody, cd3z antibody, cd247 antibody

Background: Purified Anti-Mouse CD3z Monoclonal Antibody detects the zeta subunit of the T cell receptor (TCR). The TCR complex consists of a ligand specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma, delta, eta and zeta subunits. This complex regulates assembly and expression of the receptor and is thought to be responsible for transmembrane transduction of signals after binding to TCR Studies have suggested that the CD3z subunit (also know as CD247) plays an important role in two distinct cellular compartments. In the cytoplasm, it may function to regulate Ag receptor expression and in the plasma membrane it may be required for optimal signaling by the physiologic ligand Ag/MHC. The CD3z subunit is also associated with the CD16 IgG Fc receptor on NK cells. This clone (H146-968) has been reported to work in flow cytometry (in permeabilized cells), Western Blotting and ELISA.

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway