CDH1,CDH2,CDH3,CDH4 antibody

Catalog No. ABIN7101741

Product Details

Target: CDH1,CDH2,CDH3,CDH4

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Pan Cadherin

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: CDH1,CDH2,CDH3,CDH4

Alternative Name: CDH1/CDH2/CDH3/CDH4

Background: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015],Arc-1, CD324, CDHE, ECAD, LCAM, UVO,Apoptosis,Calcium Signaling,Cancer,CDs,Cell Adhesion,Cell Adhesion_Cadherins,Cell Adhesion_Tight Junctions,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Centrosome,Cytoskeleton,ErbB-HER Signaling Pathway,Immunology & Inflammation,Invasion and Metastasis,Neuroscience,Signal Transduction,Wnt/β-Catenin Signaling Pathway,CDH1/CDH2/CDH3/CDH4

Molecular Weight: 140 kDa

Gene ID: 999, 1000, 1001

UniProt: P12830, P19022, P22223, P33151, P55283, P39038