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GAB4 antibody (AA 101-200) (Alexa Fluor 350)

GAB4 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1694018
  • Target See all GAB4 products
    GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
    Binding Specificity
    • 14
    • 8
    • 8
    • 7
    • 1
    • 1
    • 1
    AA 101-200
    Reactivity
    Human
    Host
    • 33
    Rabbit
    Clonality
    • 33
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GAB4 antibody is conjugated to Alexa Fluor 350
    Application
    • 31
    • 17
    • 14
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GAB4
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
    Alternative Name
    GAB4 (GAB4 Products)
    Synonyms
    GRB2 associated binding protein family member 4 antibody, GAB4 antibody
    Background

    Synonyms: GAB2-like, GAB4, GAB4_HUMAN, GRB2 associated binder 2 like protein, GRB2 associated binding protein family member 4, GRB2-associated binder 2-like, GRB2-associated binder 4, GRB2-associated-binding protein 2-like, GRB2-associated-binding protein 4, Growth factor receptor bound protein 2-associated protein 4.

    Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recruit-ment to RTKs. Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur. This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab 1-4 contain Pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins. The recruitment of signaling partners to Gab family members is phosphorylation-dependent. Insulin receptor and EGF receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus. Gab 4 (GRB2-associated-binding protein 4), also designated GRB2-associated-binding protein 2-like (Gab 2-like), is a 574 amino acid protein that shares 62 % sequence similarity with Gab 2 and contains one Pleckstrin homology domain.

    Gene ID
    128954
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