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FIP1L1 antibody (AA 501-594) (Alexa Fluor 488)

FIP1L1 Reactivity: Human WB, IF (p), IF (cc) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN1695208
  • Target See all FIP1L1 Antibodies
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Binding Specificity
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-594
    Reactivity
    • 25
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FIP1L1 antibody is conjugated to Alexa Fluor 488
    Application
    • 25
    • 12
    • 12
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FIP1L1
    Isotype
    IgG
    Top Product
    Discover our top product FIP1L1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Alternative Name
    FIP1L1 (FIP1L1 Products)
    Synonyms
    FIP1 antibody, Rhe antibody, hFip1 antibody, 1300019H17Rik antibody, Rje antibody, fip1l1 antibody, wu:fd36f11 antibody, zgc:103421 antibody, factor interacting with PAPOLA and CPSF1 antibody, factor interacting with PAPOLA and CPSF1 S homeolog antibody, FIP1 like 1 (S. cerevisiae) antibody, FIP1 like 1b (S. cerevisiae) antibody, fip1l1 antibody, FIP1L1 antibody, fip1l1.S antibody, Fip1l1 antibody, fip1l1b antibody
    Background

    Synonyms: DKFZp586K0717, Factor interacting with PAP, FIP1, FIP1 like 1 S cerevisiae, FIP1 like 1, FLJ33619, hFip 1, hFip1, Pre mRNA 3 end processing factor FIP1, Rearranged in hypereosinophilia, RHE, FIP1_HUMAN.

    Background: The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly(A) polymerase to process and add to the poly(A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly(A) recognition and stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.

    Gene ID
    81608
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