GMEB1 antibody (AA 301-400) (Alexa Fluor 647)

Catalog No. ABIN1699065

Product Details anti-GMEB1 Antibody (Alexa Fluor 647)

Target: GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1 (GMEB1))

Binding Specificity: AA 301-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GMEB1 antibody is conjugated to Alexa Fluor 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GMEB1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GMEB1

Target: GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1 (GMEB1))

Alternative Name: GMEB1 (GMEB1 Products)

Synonyms: MGC81052 antibody, GMEB1 antibody, si:ch211-245h7.5 antibody, pif96 antibody, p96pif antibody, MGC147529 antibody, P96PIF antibody, PIF96 antibody, 1110050A04Rik antibody, AI256615 antibody, AI481278 antibody, RGD1563208 antibody, glucocorticoid modulatory element binding protein 1 S homeolog antibody, glucocorticoid modulatory element binding protein 1 antibody, gmeb1.S antibody, GMEB1 antibody, gmeb1 antibody, Gmeb1 antibody

Background:

Synonyms: DNA binding protein p96P, DNA-binding protein p96P, Glucocorticoid modulatory element binding protein 1, Glucocorticoid modulatory element-binding protein 1, GMEB 1, GMEB-1, Gmeb1, GMEB1_HUMAN, P96P, Parvovirus initiation factor p96, P 96, P p96, P96.

Background: GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.

Gene ID: 10691