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FANCM antibody (AA 831-930) (Cy5)

FANCM Reactivity: Human IF (p), IF (cc) Host: Rabbit Polyclonal Cy5
Catalog No. ABIN1703615
  • Target See all FANCM Antibodies
    FANCM (Fanconi Anemia Complementation Group M (FANCM))
    Binding Specificity
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 831-930
    Reactivity
    • 27
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 2
    • 1
    Rabbit
    Clonality
    • 28
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FANCM antibody is conjugated to Cy5
    Application
    • 12
    • 12
    • 11
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FANCM
    Isotype
    IgG
    Top Product
    Discover our top product FANCM Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    FANCM (Fanconi Anemia Complementation Group M (FANCM))
    Alternative Name
    FANCM (FANCM Products)
    Synonyms
    FAAP250 antibody, KIAA1596 antibody, AI427100 antibody, C730036B14Rik antibody, D12Ertd364e antibody, Fanconi anemia complementation group M antibody, hypothetical protein antibody, Fanconi anemia, complementation group M antibody, FANCM antibody, PGTG_17854 antibody, Fancm antibody
    Background

    Synonyms: FAAP250, Fanconi anemia group M protein, Protein Hef ortholog,

    Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.

    Gene ID
    57697
    Pathways
    DNA Damage Repair
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