GIT2 antibody (G Protein-Coupled Receptor Kinase Interactor 2) (Cy5)

Details for Product anti-GIT2 Antibody No. ABIN1704499
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
83
37
37
4
4
2
2
2
2
2
1
1
1
Host
Rabbit
69
17
Clonality
Polyclonal
Conjugate
This GIT2 antibody is conjugated to Cy5
4
3
3
3
3
3
3
2
2
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
54
31
14
13
12
12
4
4
3
2
Options
Immunogen KLH conjugated synthetic peptide derived from human GIT2
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Git2 (GIT2 Antibody Abstract)
Background

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

Synonyms: ARF GAP GIT2, ARF GTPase activating protein GIT2, ARF GTPase-activating protein GIT2, CAT 2, CAT-2, CAT2, Cool associated tyrosine phosphorylated protein 2, Cool interacting tyrosine phosphorylated protein 2, Cool-interacting tyrosine-phosphorylated protein 2, DKFZp686G01261, G protein coupled receptor kinase interacting ArfGAP 2, G protein coupled receptor kinase interactor 2, G protein-coupled receptor kinase-interactor 2, GIT 2, GIT2, GIT2_HUMAN, GRK interacting protein 2, GRK-interacting protein 2, KIAA0148, MGC760, ARF GTPase-activating protein GIT2, Cool-interacting tyrosine-phosphorylated protein 2, G protein-coupled receptor kinase-interactor 2.

Gene ID 9815
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months