ADRM1 antibody (AA 21-120) (Cy5)

Catalog No. ABIN1704608

Product Details anti-ADRM1 Antibody (Cy5)

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRM1 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADRM1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ADRM1

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Alternative Name: ADRM1 (Adrm1 Products)

Synonyms: arm-1 antibody, gp110 antibody, rpn13 antibody, xoom antibody, ADRM1 antibody, adrm1 antibody, ARM-1 antibody, ARM1 antibody, GP110 antibody, 1110063P18Rik antibody, 2510006J17Rik antibody, AA408205 antibody, AU043535 antibody, Arm1 antibody, Gp110 antibody, Rpn13 antibody, adrm1a antibody, adrm1b antibody, fa12d09 antibody, wu:fa10g10 antibody, wu:fa12d09 antibody, zgc:56107 antibody, zgc:77256 antibody, adhesion regulating molecule 1 antibody, ADRM1 antibody, 19S proteasome regulatory subunit antibody, ADRM1 protein antibody, adrm1 antibody, ADRM1 antibody, CpipJ_CPIJ002929 antibody, SJAG_04211 antibody, Adrm1 antibody

Background:

Synonyms: 110 kDa cell membrane glycoprotein, adhesion regulating molecule 1, Adhesion-regulating molecule 1, ADRM 1, Adrm1, ADRM1_HUMAN, ARM 1, ARM-1, ARM1, GP110, hRpn13, Mr 110,000 surface antigen, Proteasomal ubiquitin receptor ADRM1, proteasome regulatory particle non ATPase 13, Proteasome regulatory particle non-ATPase 13, Regulatory particle non ATPase 13, Rpn13, Rpn13 homolog.

Background: ADRM1 is a 407 amino acid protein that localizes to both the nucleus and the cytoplasm and is thought to be involved in protein recruitment and cell adhesion. An integral membrane protein, ADRM1 functions to recruit UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, and once at the proteasome it promotes the activity of UCH-L5. Additionally, ADRM1 is thought to mediate lymphocyte adhesion in endothelial cells and may thus play a role in lymphocyte homing. ADRM1 expression is induced by IFN-g in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis. Two isoforms of ADRM1 exist due to alternative splicing events.

Gene ID: 11047

Pathways: Positive Regulation of Endopeptidase Activity