CAPG antibody (AA 251-348) (HRP)

Catalog No. ABIN1712001

Product Details anti-CAPG Antibody (HRP)

Target: CAPG (Capping Protein (Actin Filament), Gelsolin-Like (CAPG))

Binding Specificity: AA 251-348

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAPG antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Actin Regulatory Protein CAPG

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CAPG

Target: CAPG (Capping Protein (Actin Filament), Gelsolin-Like (CAPG))

Alternative Name: Actin Regulatory Protein CAPG (CAPG Products)

Synonyms: AFCP antibody, MCP antibody, gCap39 antibody, mbh1 antibody, capping actin protein, gelsolin like antibody, capping protein (actin filament), gelsolin-like antibody, CAPG antibody, Capg antibody

Background:

Synonyms: Actin capping protein GCAP39, Actin regulatory protein CAP G, Actin regulatory protein CAP-G, AFCP, CAPG, CAPG_HUMAN, Capping protein actin filament gelsolin like, Capping protein gelsolin like, gCap39, Gelsolin like capping protein, Macrophage capping protein, Macrophage-capping protein, mbh1, MCP, Myc basic mot homolog 1.

Background: Caldesmon, Filamin 1, Nebulin, Plastin, ADF, Gelsolin, CapG, Dematin and Cofilin are differentially expressed Actin-binding proteins. Both muscular (CDh) and non-muscular (CD1) forms of Caldesmon bind to Actin as well as to Calmodulin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CD1 is widely expressed in non-muscle tissues and cells. CapG, also designated Actin-regulatory protein and macrophage-capping protein, is a macrophage-specific protein that reversibly blocks the barbed ends of Actin filaments, but does not sever preformed ones. The interactions of CapG with Actin may be important in the regulation of nuclear and cytoplasmic structures. CapG is a calcium-sensitive DNA-binding protein that plays a role in macrophage function. It is expressed in macrophages and macrophage-like cells and can localize both to the nucleus and the cytoplasm.

Gene ID: 822

Pathways: Regulation of Actin Filament Polymerization