GLTSCR2 antibody (AA 401-478) (HRP)

Catalog No. ABIN1712325

Product Details anti-GLTSCR2 Antibody (HRP)

Target: GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))

Binding Specificity: AA 401-478

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLTSCR2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GLTSCR2

Target: GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))

Alternative Name: GLTSCR2/PICT1 (GLTSCR2 Products)

Synonyms: GLTSCR2 antibody, pict1 antibody, pict-1 antibody, MGC115044 antibody, PICT-1 antibody, PICT1 antibody, 5330430H08Rik antibody, 9430097C02Rik antibody, AU041936 antibody, AW536441 antibody, R74911 antibody, NOP53 ribosome biogenesis factor antibody, NOP53 ribosome biogenesis factor L homeolog antibody, Nop53 antibody, NOP53 antibody, nop53 antibody, nop53.L antibody

Background:

Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.

Background: The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

Gene ID: 29997