NAC1 antibody (AA 311-400) (HRP)

Catalog No. ABIN1712365

Product Details anti-NAC1 Antibody (HRP)

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Binding Specificity: AA 311-400

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAC1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NAC1/BTBD14B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NAC1

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Alternative Name: NAC1/BTBD14B (NACC1 Products)

Synonyms: BEND8 antibody, BTBD14B antibody, BTBD30 antibody, NAC-1 antibody, NAC1 antibody, NACC1 antibody, 2010001H03Rik antibody, 4930511N13Rik antibody, Btbd14b antibody, Nac1 antibody, Nac-1 antibody, nucleus accumbens associated 1 antibody, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing antibody, NACC1 antibody, Nacc1 antibody

Background:

Synonyms: BEND8, BTB Domain Containing 14B, BTB/POZ domain-containing protein 14B, btbd14b, btbd14b, FLJ37383, NAC-1, NAC1, Nacc1, NACC1_HUMAN, Nucleus accumbens-associated protein 1.

Background: NAC1 is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homooligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis.

Gene ID: 112939