SH3KBP1 antibody (AA 201-300)

Catalog No. ABIN1713895

Product Details anti-SH3KBP1 Antibody

Target: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Binding Specificity: AA 201-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3KBP1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SH3KBP1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SH3KBP1

Target: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Alternative Name: SH3KBP1 (SH3KBP1 Products)

Synonyms: CD2BP3 antibody, CIN85 antibody, GIG10 antibody, HSB-1 antibody, HSB1 antibody, MIG18 antibody, 1200007H22Rik antibody, 1700125L08Rik antibody, 5830464D22Rik antibody, AI447724 antibody, IN85 antibody, Ruk antibody, Seta antibody, SH3 domain containing kinase binding protein 1 antibody, SH3-domain kinase binding protein 1 antibody, SH3 domain-containing kinase-binding protein 1 antibody, SH3KBP1 antibody, sh3kbp1 antibody, LOC100551401 antibody, Sh3kbp1 antibody

Background:

Synonyms: c Cbl interacting protein, Cbl interacting protein, Cbl interacting protein of 85 kDa, Cbl-interacting protein of 85 kDa, CD2 binding protein 3, CD2-binding protein 3, CD2BP3, CIN 85, CIN85, GIG 10, GIG10, HSB 1, HSB-1, HSB1, Human Src family kinase binding protein 1, Human Src family kinase-binding protein 1, MIG 18, MIG18, Migration inducing gene 18, Migration inducing gene 18 protein, SH3 domain kinase binding protein 1, SH3 domain-containing kinase-binding protein 1, SH3BP 1, SH3K1_HUMAN, SH3KBP1, Src family kinase binding protein 1, src related kinase binding protein 1.

Background: SHKBP1 is a 707 amino acid protein belonging to the KCTD3 family. Acting downstream of Flt-3/Flk-2, SHKBP1 interacts with CIN85. SHKBP1 contains a BTB/POZ domain, which is involved in ring canal formation and chromatin folding, and five WB repeats. SHKBP1 exists as two alternatively spliced isoforms and maps to human chromosome 19q13.2. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs).

Pathways: EGFR Signaling Pathway, EGFR Downregulation