Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

NR1H4 antibody (AA 175-280)

NR1H4 Reactivity: Human, Rat, Mouse WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1714781
  • Target See all NR1H4 Antibodies
    NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
    Binding Specificity
    • 15
    • 12
    • 9
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 175-280
    Reactivity
    • 55
    • 27
    • 26
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    Human, Rat, Mouse
    Host
    • 52
    • 5
    • 1
    Rabbit
    Clonality
    • 53
    • 5
    Polyclonal
    Conjugate
    • 28
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NR1H4 antibody is un-conjugated
    Application
    • 50
    • 26
    • 12
    • 12
    • 12
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Bile Acid Receptor NR1H4
    Isotype
    IgG
    Top Product
    Discover our top product NR1H4 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zhao, Elhafiz, Jiang, Das, Li, Zhou, Fan, Wang, Yuan, Xu, Jiang, Zhang, Wang: "Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity." in: Toxicology and applied pharmacology, Vol. 362, pp. 150-158, (2019) (PubMed).

    Yang, Mei, Xu, Zhou, Zhu, Sun, Huang, Wang, Shu, Liu, Ding, Hassan, Zhang, Jiang: "Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 110, pp. 1-12, (2018) (PubMed).

    Zhang, Hwang, Oh, Park, Chung, Lee, Baek, Ryoo, Woo: "Effects of the fibrous topography-mediated macrophage phenotype transition on the recruitment of mesenchymal stem cells: An in vivo study." in: Biomaterials, Vol. 149, pp. 77-87, (2018) (PubMed).

    Yu, Liu, Yuan, Li, Yang, Yuan, Sun, Zhang, Jiang: "SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model." in: Frontiers in pharmacology, Vol. 8, pp. 256, (2017) (PubMed).

    Zhou, Lin, Chen, Wang, Liu, Xia: "Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice." in: The British journal of nutrition, Vol. 114, Issue 4, pp. 509-18, (2015) (PubMed).

  • Target
    NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
    Alternative Name
    Bile Acid Receptor NR1H4 (NR1H4 Products)
    Synonyms
    zgc:110190 antibody, zgc:92742 antibody, NR1H4 antibody, BAR antibody, FXR antibody, HRR-1 antibody, HRR1 antibody, RIP14 antibody, AI957360 antibody, Fxr antibody, Rxrip14 antibody, nuclear receptor subfamily 1, group H, member 5 S homeolog antibody, nuclear receptor subfamily 1, group H, member 4 antibody, nuclear receptor subfamily 1 group H member 4 antibody, nr1h5.S antibody, nr1h4 antibody, NR1H4 antibody, Nr1h4 antibody
    Background

    Synonyms: BAR, FXR, HRR1, HRR-1, PFIC5, RIP14, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4

    Background: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed orphan receptors? because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

    Gene ID
    9971
    UniProt
    Q96RI1
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
You are here:
Support