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HHATL antibody (AA 25-125)

HHATL Reactivity: Human WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1714831
  • Target See all HHATL Antibodies
    HHATL (Hedgehog Acyltransferase-Like (HHATL))
    Binding Specificity
    • 14
    • 2
    • 1
    AA 25-125
    Reactivity
    • 17
    • 2
    • 2
    Human
    Host
    • 16
    • 1
    Rabbit
    Clonality
    • 16
    • 1
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HHATL antibody is un-conjugated
    Application
    • 16
    • 12
    • 12
    • 4
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HHATL/GUP1
    Isotype
    IgG
    Top Product
    Discover our top product HHATL Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    HHATL (Hedgehog Acyltransferase-Like (HHATL))
    Alternative Name
    HHATL/GUP1 (HHATL Products)
    Synonyms
    Gup1 antibody, RGD1311911 antibody, gup1 antibody, oact3 antibody, mboat3 antibody, MGC53261 antibody, mstp002 antibody, MGC89797 antibody, GUP1 antibody, 1110011D13Rik antibody, C3orf3 antibody, MBOAT3 antibody, MSTP002 antibody, OACT3 antibody, c3orf3b antibody, gup1b antibody, im:7145545 antibody, wu:fc04e05 antibody, zgc:154131 antibody, c3orf3a antibody, gup1a antibody, zgc:77750 antibody, hedgehog acyltransferase-like antibody, hedgehog acyltransferase like S homeolog antibody, hedgehog acyltransferase like antibody, hedgehog acyltransferase like, b antibody, hedgehog acyltransferase like, a antibody, Hhatl antibody, hhatl.S antibody, HHATL antibody, hhatl antibody, hhatlb antibody, hhatla antibody
    Background

    Synonyms: C3orf3, Glycerol uptake/transporter homolog, GUP1, GUP1 glycerol uptake/transporter homolog, Hedgehog acyltransferase like, Hedgehog acyltransferase-like protein, Hhatl, HHATL_HUMAN, KIAA1173, MBOAT3, Membrane bound O acyltransferase domain containing 3, MSTP002, OACT3, Protein-cysteine N-palmitoyltransferase HHAT-like protein.

    Background: GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.

    Gene ID
    57467
    Pathways
    Hedgehog Signaling
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