ATP2B1 antibody (AA 351-450)

Catalog No. ABIN1714863

This anti-ATP2B1 antibody is a Rabbit Polyclonal antibody detecting ATP2B1 in WB, ELISA, IHC (p), IHC (fro), ICC, IF (cc) and IF (p). Suitable for Human and Dog.

Quick Overview for ATP2B1 antibody (AA 351-450) (ABIN1714863)

Target: ATP2B1 (ATPase, Ca++ Transporting, Plasma Membrane 1 (ATP2B1))

Reactivity: Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP2B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ATP2B1 Antibody

Binding Specificity: AA 351-450

Cross-Reactivity: Dog, Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PMCA1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ATP2B1

Target: ATP2B1 (ATPase, Ca++ Transporting, Plasma Membrane 1 (ATP2B1))

Alternative Name: PMCA1

Background:

Synonyms: ATP2B1, AT2B1_HUMAN, ATP2B1, ATPase Ca++ transporting plasma membrane 1, Plasma membrane calcium ATPase 1, Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1, Plasma membrane calcium transporting ATPase 1, Plasma membrane calcium-transporting ATPase 1, PMCA 1, PMCA1.

Background: Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA1 (ATP2B1) is a ubiquitously expressed form of the PMCA calcium exporter family.

Gene ID: 3820

UniProt: P20020

Pathways: Ribonucleoside Biosynthetic Process