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EPAS1 antibody (AA 535-631)

EPAS1 Reactivity: Human, Mouse, Rat, Hamster WB, ELISA, IHC, IP, FACS, ICC, IF, ChIP Host: Mouse Monoclonal ep190b unconjugated
Catalog No. ABIN363209
  • Target See all EPAS1 Antibodies
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Binding Specificity
    • 16
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 535-631
    Reactivity
    • 92
    • 48
    • 42
    • 18
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Hamster
    Host
    • 101
    • 10
    • 1
    • 1
    Mouse
    Clonality
    • 93
    • 20
    Monoclonal
    Conjugate
    • 57
    • 14
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This EPAS1 antibody is un-conjugated
    Application
    • 92
    • 46
    • 31
    • 23
    • 15
    • 13
    • 13
    • 13
    • 13
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)
    Specificity
    Reacts with HIF-2 alpha from human, mouse hamster and rat
    Cross-Reactivity (Details)
    Does not cross-react with HIF-1 alpha.
    Purification
    Purified (protein G)
    Immunogen
    Human HIF-2 alpha amino acids 535-631
    Clone
    Ep190b
    Isotype
    IgG1
    Top Product
    Discover our top product EPAS1 Primary Antibody
  • Application Notes

    Working dilution: Optimal dilution should be determined by the end user.
    The following are guidelines only:
    ELISA1:100-1:2000, FC1:400, IHC1:150-1:300, WB1:500

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, Sodium azide 0.1 %
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
  • Target
    EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
    Alternative Name
    Hypoxia-Inducible Factor 2-alpha (EPAS1 Products)
    Synonyms
    EPAS1 antibody, ECYT4 antibody, HIF2A antibody, HLF antibody, MOP2 antibody, PASD2 antibody, bHLHe73 antibody, HIF-2alpha antibody, HRF antibody, Hif2a antibody, bhlhe73 antibody, ecyt4 antibody, hif2 antibody, hif2a antibody, hif2alpha antibody, hlf antibody, mop2 antibody, pasd2 antibody, EPAS antibody, EPAS-1 antibody, endothelial PAS domain protein 1 antibody, endothelial PAS domain protein 1 L homeolog antibody, EPAS1 antibody, epas1 antibody, Epas1 antibody, epas1.L antibody
    Background
    Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
    Gene ID
    2034
    UniProt
    Q99814
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect
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