ATP2C1 antibody

Catalog No. ABIN1724719

Product Details anti-ATP2C1 Antibody

Target: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Reactivity: Human, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATP2C1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of ATP2C1 expressed in E. coli.

Clone: 4G12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-ATP2C1 antibody (ABIN1724719)

Yokota, Sawamura: "Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).

Majore, Biolcati, Barboni, Cannistraci, Binni, Crisi, Picardo, Grammatico: "ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease." in: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 933-5, (2005) (PubMed).

Target Details for ATP2C1

Target: ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))

Alternative Name: ATP2C1 (ATP2C1 Products)

Background:

Description: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.

Aliases: HHD, BCPM, PMR1, SPCA1

Molecular Weight: 100 kDa

Gene ID: 27032

HGNC: 27032

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process