C17orf53 antibody (AA 282-527)

Catalog No. ABIN1724778

Product Details anti-C17orf53 Antibody

Target: C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))

Binding Specificity: AA 282-527

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C17orf53 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. coli.

Clone: 5F3H1

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-C17orf53 antibody (ABIN1724778)

Styrkarsdottir, Halldorsson, Gretarsdottir, Gudbjartsson, Walters, Ingvarsson, Jonsdottir, Saemundsdottir, Snorradóttir, Center, Nguyen, Alexandersen, Gulcher, Eisman, Christiansen, Sigurdsson, Kong et al.: "New sequence variants associated with bone mineral density. ..." in: Nature genetics, Vol. 41, Issue 1, pp. 15-7, (2008) (PubMed).

Target Details for C17orf53

Target: C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))

Alternative Name: C17ORF53 (C17ORF53 Products)

Synonyms: chromosome 17 open reading frame 53 antibody, C17orf53 antibody

Background: C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. , ,

Molecular Weight: 69.8 kDa

Gene ID: 78995

HGNC: 78995