alpha 2 Macroglobulin antibody (alpha-2-Macroglobulin)

Details for Product anti-A2M Antibody No. ABIN1731392
Antigen
Reactivity
Human, Rat (Rattus)
214
47
39
7
5
4
3
3
1
Host
Rabbit
167
58
41
9
4
1
1
Clonality
Polyclonal
Conjugate
This alpha 2 Macroglobulin antibody is un-conjugated
28
15
13
8
8
6
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
179
147
68
36
20
19
12
11
11
11
9
9
8
7
3
1
1
Options
Immunogen Synthetic peptide from human A2M / Alpha-2-Macroglobulin.
Isotype IgG
Specificity Reacts with the C-terminus part of human A2M / Alpha-2-Macroglobulin
Cross-Reactivity Rat (Rattus)
Cross-Reactivity (Details) Cross reacts with rat protein.
Purification Antigen affinity purified
Antigen
Alternative Name A2M / alpha-2-Macroglobulin (A2M Antibody Abstract)
Background Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
UniProt P01023
Pathways Lipid Metabolism
Application Notes

Working dilution: ELISA, IHC-P (10 μg/mL), WB (1 μg/mL)

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, glycerol 50 % , Sodium azide 0.01 %
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Supplier Images
Image no. 1 for anti-alpha-2-Macroglobulin (A2M) antibody (ABIN1731392) anti-alpha-2-Macroglobulin (A2M) antibody