AAK1 antibody (C-Term)

Details for Product anti-AAK1 Antibody No. ABIN1731398
Antigen
Epitope
C-Term
16
12
12
10
7
7
4
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
93
64
44
6
6
5
5
5
4
2
1
1
1
Host
Rabbit
98
7
6
Clonality
Polyclonal
Conjugate
This AAK1 antibody is un-conjugated
6
5
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
91
53
26
13
12
10
7
6
2
2
2
1
1
Options
Immunogen Aak1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of the human Aak1.
Isotype IgG
Specificity Reacts with human Aak1
Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Cross reacts with proteins from mouse and rat.
Purification Antigen affinity purified
Antigen
Background Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
UniProt Q2M2I8
Application Notes

Working dilution: IHC - P (5 μg/mL), WB (1 - 2 μg/mL)

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, Sodium azide 0.02 %
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Supplier Images
Image no. 1 for anti-AAK1 (C-Term) antibody (ABIN1731398) anti-AAK1 (C-Term) antibody (Image 1)
Image no. 2 for anti-AAK1 (C-Term) antibody (ABIN1731398) anti-AAK1 (C-Term) antibody (Image 2)